Whether or not EPD is effective, it does appear to be safe. No serious adverse reactions have been associated with its use. Although in theory allergic reactions could occur in response to EPD injections, the amount of allergen used in EPD is so much lower than the amount used in a normal "allergy shot" that these may not, in fact, occur.
EPD proponents claim that there can be a temporary aggravation response that is part of the healing process; however, this has not been documented.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
Galli E, Bassi MS, Mora E, et al. A double-blind randomized placebo-controlled trial with short-term beta-glucuronidase therapy in children with chronic rhinoconjunctivitis and/or asthma due to dust mite allergy.
J Investig Allergol Clin Immunol