Sickle Cell Disease
Principal Proposed Natural Treatments
Principal Proposed Natural Treatments
Other Proposed Natural Treatments
1 Zemel BS, Kawchak DA, Fung EB, et. al. Effect of zinc supplementation on growth and body composition in children with sickle cell disease. Am J Clin Nutr. 2002;75:300–307.
2 Gupta VL, Chaubey BS. Efficacy of zinc therapy in prevention of crisis in sickle-cell anemia: a double-blind, randomized controlled clinical trial. J Assoc Physicians India. 1995;43:467–469.
3 Serjeant GR, Galloway RE, Gueri MC. Oral zinc sulphate in sickle-cell ulcers. Lancet. 1970;2:891–893.
4 Tomer A, Kasey S, Connor WE, et al. Reduction of pain episodes and prothrombotic activity in sickle cell disease by dietary n-3 fatty acids. Thromb Haemost. 2001;85:966–974.
5 Ajayi OA, George BO, Ipadeola T. Clinical trial of riboflavin in sickle cell disease. East Afr Med J. 1993;70:418–421.
6 al-Momen AK. Diminished vitamin B12 levels in patients with severe sickle cell disease. J Intern Med. 1995;237:551–555.
7 Ballas SK. Short Report: Hydration of sickle erythrocytes using a herbal extract ( Pfaffia paniculata ) in vitro. Br J Haematol. 2000;111:359–362.
8 Chiu D, Vichinsky E, Ho SL, et al. Vitamin C deficiency in patients with sickle cell anemia. Am J Pediatr Hematol Oncol. 1990;12:262–267.
9 De Franceschi L, Bachir D, Balacteros F, et al. Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease. J Clin Invest. 1997;100:1847–1852.
10 De Franceschi L, Bachir D, Balacteros F, et al. Oral magnesium pidolate: effects of long-term administration in patients with sickle cell disease. Br J Haematol. 2000;108:284–289.
11 Essein, EU. Plasma levels of retinol, ascorbic acid and alpha-tocopherol in sickle cell anemia. Centr Afr J Med. 1995;41:48–50.
12 Flores L, Pais R, Buchanan I, et al. Pyridoxal 5’-phosphate levels in children with sickle cell disease. Am J Pediatr Hematol Oncol. 1988;10:236–240.
13 Jain SK, Ross JD, Duett J, et al. Low plasma prealbumin and carotenoid levels in sickle cell disease patients. Am J Med Sci. 1990;229:13–15.
14 Jain SK, Williams DM. Reduced levels of plasma ascorbic acid (vitamin C) in sickle cell disease patients: its possible role in the oxidant damage to sickle cells in vitro. Clin Chim Acta. 1985;149:257–261.
15 Kark JA, Kale MP, Tarassoff PG, et al. Inhibition of erythrocyte sickling in vitro by pyridoxal. J Clin Invest. 1978;62:888–891.
16 Kark JA, Tarassoff PG, Bongiovanni R. Pyridoxal phosphate as an antisickling agent in vitro. J Clin Invest. 1983;71:1224–1229.
17 Muskiet FA, Muskiet FD, Meiborg G, et al. Supplementation of patients with homozygous sickle cell disease with zinc, alpha-tocopherol, vitamin C, soybean oil, and fish oil. Am J Clin Nutr. 1991;54:736–744.
18 Natta C, Stacewicz-Sapuntzakis M, Bhagavan H, et al. Low serum levels of carotenoids in sickle cell anemia. Eur J Haematol. 1988;41:131–135.
19 Natta CL, Machlin LJ, Brin M. A decrease in irreversibly sickled erythrocytes in sickle cell anemia patients given vitamin E. Am J Clin Nutr. 1980;33:968–971.
20 Natta CL, Reynolds RD. Apparent vitamin B6 deficiency in sickle cell anemia. Am J Clin Nutr. 1984;40:235–239.
21 Ndombi IO, Kinoti SN. Serum vitamin E and the sickling status in children with sickle cell anemia. East Afr Med J. 1990;67:720–725.
22 Ohnishi ST, Ohnishi T, Ogunmola GB. Sickle cell anemia: A potential nutritional approach for a molecular disease. Nutrition. 2000;16:330–338.
23 Osifo BO, Adeyokunnu A, Parmentier Y, et al. Abnormalities of serum transcobalamins in sickle cell disease (HbSS) in Black Africa. Scand J Haematol. 1983;30:135–140.
24 Phillips G, Tangney CC. Relationship of plasma alpha tocopherol to index of clinical severity in individuals with sickle cell anemia. Am J Hematol. 1992;41:227–231.
25 Reed JD, Redding-Lallinger R, Orringer EP. Nutrition and sickle cell disease. Am J Hematol. 1987;24:441–455 .
26 Tangney CC, Phillips G, Bell RA, et al. Selected indices of micronutrient status in adult patients with sickle cell anemia (SCA). Am J Hematol. 1989;32:161–166.
27 van der Dijs FP, Schnog JJ, Brouwer DA, et al. Elevated homocysteine levels indicate suboptimal folate status in pediatric sickle cell patients. Am J Hematol. 1998;59:192–198.
28 Wambebe C, Khamofu H, Momoh JA, et al. Double-blind, placebo-controlled, randomised cross-over clinical trial of NIPRISAN in patients with Sickle Cell Disorder. Phytomedicine . 2001;8:252–261.
29 Bao B, Prasad AS, Beck FW, et al. Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients. Transl Res. 2008;152:67-80.
30 Adegoke SA, Shehu UA, et al. Influence of lime juice on the severity of sickle cell anemia. J Altern Complement Med. 2013;19(6):588-592.
- Reviewer: EBSCO CAM Review Board
- Review Date: 08/2013 -
- Update Date: 00/42/2014 -